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Major histocompatibility complex, class I, C
Symbol(s) HLA-C; Cw*1701; D6S204; FLJ27082; HLA-JY3; HLC-C; PSORS1
External IDs OMIM: 142840 Homologene86715
RNA expression pattern

PBB GE HLA-C 209140 x at tn.png

PBB GE HLA-C 216526 x at tn.png

PBB GE HLA-C 208729 x at tn.png

More reference expression data

Human Mouse
Entrez 3107 667977
Ensembl ENSG00000204525 na
Uniprot P10321 na
Refseq XM_001131707 (mRNA)
XP_001131707 (protein)
XM_001003863 (mRNA)
XP_001003863 (protein)
Location Chr 6: 31.34 - 31.35 Mb na
Pubmed search [1] [2]

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

Disease Associations

By Serotype

Cw1: Multinodular goiters[1]

By Allele

Cw*16: B chronic lymphocytic leukaemia[2]



  • Cw1 Serotype: Cw*0102 and Cw*0109
  • Cw11 ?
  • Cw*0104 to *0108


  • Cw2 Serotype: Cw*0202 and *0208
  • Cw*0203 to *0207, and 0209


  • Cw9 Serotype: Cw*0303
  • Cw10 Serotype: Cw*0302, *0304, and *0306
  • Cw3 Serotype: Cw*0307
  • Cw*0305 and 0308


  • Cw4 Serotype: Cw*0401, *0407, and *0410


  • Cw5 Sertoype: Cw*0501 and *0502
  • Cw*0503 to *506 and *0508 to *0510


  • Cw6 Serotype: Cw*0602 and *0605
  • Cw6*0603, *0604 and *0606 to *0611

  • Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
  • Cw*0707 to *0711, *0713, *0715, and *0717 to *0729


  • Cw8 Serotype: Cw*0801, *0802 and *0803
  • Cw*805 to *0812

Cw*1202 to *1215

Cw*1402 to *1405

Cw*1501 to *1511

Cw*1601 to *1606

Cw*1701 to *1703

Cw*1801 and *1802

Common Haplotype

Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)


  1. Ríos A, Rodríguez J, Moya M, Galindo P, Canteras M, Alvarez M, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg. 141 (2): 123–8. PMID 16490887. 
  2. Montes-Ares O, Moya-Quiles M, Montes-Casado M, Guerra-Pérez N, Campillo J, González C, López-Bermejo A, Tamayo M, Majado M, Parrado A, Muro M, Marín L, Alvarez-López M (2006). "Human leucocyte antigen-C in B chronic lymphocytic leukaemia.". Br J Haematol. 135 (4): 517–9. PMID 17054674. 

Further reading

  • Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. PMID 11463741. doi:10.1093/embo-reports/kve141. 
  • Greenway AL, Holloway G, McPhee DA; et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. PMID 12734410. 
  • Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. PMID 12836198. 
  • Leavitt SA, SchOn A, Klein JC; et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1–8. PMID 14965316. 
  • Tolstrup M, Ostergaard L, Laursen AL; et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res. 2 (2): 141–51. PMID 15078178. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726. 
  • Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports. 1 (1): 47–53. PMID 16091223. 

External links