HLA-A74

Jump to: navigation, search


major histocompatibility complex (human), class I, A74
Alleles A*7401 </br> A*7403
Structure (See HLA-A)
Identifiers
7401 7403
Symbol(s) HLA-A
EBI-HLA A*7401
EBI-HLA A*7403
Shared data
Locus chr.6 6p21.31

HLA-A74 (A74) is an HLA-A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.


Serotype

A74, A19 serotype recognition of Some HLA A*74 allele-group gene products[1]
A*74 A74 A19 Sample
allele  %  % size (N)
7401 40 11 119
7401 17 29


Disease associations

A significant association has been found between A74 and nasal polyposis.[2]

A*74 allele Frequencies

HLA A*7401 frequencies
freq
ref. Population (%)
[3] Kenya 9.7
[3] Cameroon Beti 8.3
[3] Guinea Bissau 7.7
[3] Burkina Faso Mossi 6.6
[3] Uganda Kampala 5.2
[3] Cameroon Yaounde 5.0
[3] Cameroon Bamileke 4.5
[3] Cameroon Sawa 3.8
[3] Mali Bandiagara 3.6
[3] Iran Baloch 2.8
[3] Zimbabwe Harare Shona 2.7
[3] Senegal Niokholo Mandenka 2.2
[3] Burkina Faso Rimaibe 2.1
[3] Kenya Nandi 1.7
[3] Morocco Nador Metalsa 1.4
[3] Thailand Northeast 1.2
[3] Thailand 1.1
[3] Jordon Amman 0.7
[3] Jordon Amman 0.5
[3] China South 0.5
HLA A*7403 frequencies
freq
ref. Population (%)
[3] Kenya Luo 7.3
[3] Iran Baloch 0.6
[3] Kenya 0.3
[3] Uganda Kampala 0.3

References

  1. derived from IMGT/HLA
  2. Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 257 (3): 137–9. PMID 10839486. 
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660.  External link in |title= (help)



Linked-in.jpg