HLA-A66

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


major histocompatibility complex (human), class I, A66
Alleles A*6601 </br> A*6602 </br> A*6603
Structure (See HLA-A)
Identifiers
6601 6602 6603
Symbol(s) HLA-A
EBI-HLA A*6601
EBI-HLA A*6602
EBI-HLA A*6603
Shared data
Locus chr.6 6p21.31

Overview

HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.


Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products[2]
A*66 A66 A10 A26 Other Sample
allele  %  %  %  % size (N)
6601 20 10 61 3 799
6602 38 10 4 31 205
6603 32 7 7 18 28

A*6601 Frequencies

HLA A*6601 frequencies
freq
ref. Population (%)
[3] Cameroon Sawa 7.7
[3] Kenya Luo 6.8
[3] Cameroon Sawa 7.7
[3] Cameroon Bakola Pygmy 5.8
[3] Cameroon Baka Pygmy 5.0
[3] Kenya Nandi 5.0
[3] Zimbabwe Harare Shona 0.2
[3] Cameroon Baka Pygmy 5.0
[3] Cameroon Beti 4.6
[3] Cameroon Bamileke 4.5
[3] India West Bhils 4.0
[3] Zimbabwe Harere Shona 3.8
[3] Uganda Kampala 3.8
[3] India Mumbia Marathas 2.5
[3] Cape Verde Northwestern 2.5
[3] Czech republic 2.4
[3] Morocco Nador Metalsa 2.1
[3] Central Portugal 2.0
[3] India West Parsis 2.0
[3] South Africian Natal Zulu 2.0
[3] Kenya 1.7
[3] Tunisia Tunis 1.7
[3] Guinea Bissau 1.5
[3] Georgia Tibilisi 1.4
[3] Zambia Lusaka 1.2
[3] Italy Bergamo 1.1
[3] Pakistan Karachi Parsi 1.1
[3] Oman 0.8
[3] Sudanese 0.8
[3] Belgium 0.5
[3] Southeast France 0.4
[3] Mongolia Buriat 0.4
[3] Wales 0.2
HLA A*6602 frequencies
freq
ref. Population (%)
[3] South Africian Natal Zulu 1.5
[3] Cameroon Yaounde 1.1
[3] Cameroon Bamileke 0.6
[3] Senegal Niokholo Mandenka 0.5
[3] Kenya Nandi 0.4
[3] Zimbabwe Harare Shona 0.2
[3] Wales 0.03
HLA A*6603 frequencies
freq
ref. Population (%)
[3] Cameroon Pygmy Baka 10.0
[3] Cameroon Bakola Pygmy 9.0
[3] Cameroon Sawa 7.7
[3] CAR Mbenzele Pygmy 2.8
[3] Zimbabwe Harare Shona 0.2


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References

  1. Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. PMID 8475492. 
  2. derived from IMGT/HLA
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660.  External link in |title= (help)



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