HLA-A36

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major histocompatibility complex (human), class I, A36
Alleles A*3601 </br>
Structure (See HLA-A)
Identifiers
3601
Symbol(s) HLA-A
EBI-HLA A*3601
Locus chr.6 6p21.31

HLA-A36 (A36) is a rare HLA-A serotype. The serotype identifies the more common HLA-A*36 gene products. A36 is more common in Africans.

Serotype

A36 and A1 serotype recognition of Some HLA A*3601 allele-group gene products[1]
A*36 A36 A1 Sample
allele  %  % size (N)
3601 68 16 807


Distribution

HLA A36 frequencies
freq
ref. Population (%)
Kenya 6.6
[2] N. African (non-caucasian) 4.5
[3] Mossi(Burkino Faso) 3.8
[4] Beti(Cameroon) 3.7
[2] Mongolian 3.1
Lusaka(Zambia) 3.1
[2] Harare Shona (Zimbabwe) 2.9
[2] Uygars(China) 2.6
[4] Bamileke(Cameroon) 2.6
[5] Amman(Jordon) 2.4
[3] Fulani 2.0
[2] Sweden 1.6
Tswana (S. Africa) 1.2
Kampala (Uganda) 1.2
[2] Spain 0.9
Bubi(Eq. Guinea) 0.5
[2]  !kung (San) 0.0
Berber(Morroco) 0.0

A36 is largely limited to Africa. Outside of Africa more than half of the populations have no A36 and the majority that do, have only trace levels. The exception is in Central/East Central Asia. This appears not to be coincidental. HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in which the DR3-DQ2 (notably DRB1*0302) and A*33-B*58 haplotypes were carried into and redistributed from Central Asia into the surrounding populations.

References

  1. derived from IMGT/HLA
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-262390-7. 
  3. 3.0 3.1 Modiano D, Luoni G, Petrarca V; et al. (2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue Antigens. 57 (2): 128–37. PMID 11260507. 
  4. 4.0 4.1 Torimiro JN, Carr JK, Wolfe ND; et al. (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. PMID 16451198. doi:10.1111/j.1399-0039.2005.00527.x. 
  5. Sánchez-Velasco P, Karadsheh NS, García-Martín A, Ruíz de Alegría C, Leyva-Cobián F (2001). "Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations". Hum. Immunol. 62 (9): 901–9. PMID 11543892. 



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