HLA-A32

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major histocompatibility complex (human), class I, A32
Alleles A*3201 </br> A*3202 </br> A*3204
Structure (See HLA-A)
Identifiers
3201 3202 3204
Symbol(s) HLA-A
EBI-HLA A*3201
EBI-HLA A*3202
EBI-HLA A*3204
Locus chr.6 6p21.31

HLA-A32 (A32) is an HLA-A serotype. The serotype identifies the more common HLA-A*32 gene products. A32 is a split antigen of the A19 serotype group. This group also includes A29, A30, A31, A33, and A74 serotypes

Serotype

A32 serotype recognition of Some HLA A*32 allele-group gene products[1]
A*32 A32 A19 Sample
allele  %  % size (N)
A3201 94 3441
A3202 67 3
A3201 17 17 6

Serotyping efficiency for the predominant allele is good. There are 16 known alleles that result in 15 isoforms of HLA-A32. One isoform may be poorly expressed.[2]


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HLA-A*3201 allele frequencies

HLA A*3201 frequencies
freq
ref. Population (%)
[3] Oman 11.4
[3] Pakistan Brahui 9.2
[3] Italy Sardinia (3) 8.7
[3] Bulgaria 8.2
[3] Burkina Faso Fulani 8.2
[3] Pakistan Karachi Parsi 7.8
[3] Pakistan Kalash 7.5
[3] France South East 7.2
[3] Pakistan Baloch 7.1
[3] Georgia Tibilisi Kurds 6.7
[3] Iran Baloch 6.7
[3] Italy Bergamo 5.9
[3] India North Hindus 5.8
[3] Croatia 5.7
[3] France Corsica 5.5
[3] Sudanese 5.5
[3] Pakistan Pathan 5.1
[3] Pakistan Sindhi 5.1
[3] Romanian 5.0
[3] Cape Verde NW Islands 4.8
[3] Georgia Tibilisi Georgians 4.8
[3] Bulgaria Gipsy 4.2
[3] Cape Verde SE Islands 4.0
[3] Israel Arab Druse 4.0
[3] Portugal Centre 4.0
[3] Spain Majorca and Minorca 3.9
[3] Burkina Faso Mossi 3.8
[3] Guinea Bissau 3.8
[3] Belgium 3.7
[3] Cuban Mulatto 3.6
[3] Cuban White 3.6
[3] Australia New South Wales 3.4
[3] Morocco Nador Metalsa 3.4
[3] Ireland Northern 3.2
[3] Jordan Amman 3.1
[3] Portugal South 3.1
[3] India Khandesh Pawra 3.0
[3] India New Delhi 3.0
[3] India West Coast Parsis 3.0
[3] Azores Central Islands 2.7
[3] India North Delhi 2.7
[3] Pakistan Burusho 2.7
[3] Kenya Luo 2.6
[3] Spain Eastern Andalusia Gipsy 2.6
[3] South Africian Natal Zulu 2.5
[3] China North Han 2.4
[3] Czech Republic 2.4
[3] Mexico Mestizos 2.4
[3] China Beijing 2.2
[3] Finland 2.2
[3] Uganda Kampala 2.2
[3] Russia Tuva pop 2 2.1
[3] Brazil 2.0
[3] Cameroon Beti 2.0
[3] Cape Yk P. (Indig. Aust.) 1.9
[3] Italy North pop 1 1.9
[3] Kenya Nandi 1.9
[3] Tunisia 1.5
[3] Georgia Svaneti Svans 1.3
[3] New Caledonia 1.2
[3] Golla (Andhra Prad. India) 1.1
[3] Senegal Niokholo Mandenka 1.1
[3] Thailand 1.1
[3] Cameroon Bakola Pygmy 1.0
[3] China Inner Mongolia 1.0
[3] Kenya 1.0
[3] Javanese (Singapore) 1.0
[3] South Africa Natal Tamil 1.0
[3] Basque (Gipuzkoa, Spain) 1.0
[3] China Qinghai Hui 0.9
[3] Tibet (china) 0.9
[3] Zimbabwe Harare Shona 0.9
[3] Beijing Shijiazhuang Tianjian 0.8
[3] Groote Eylandt (Indig. Austr.) 0.7
[3] Mali Bandiagara 0.7
[3] Singapore Chinese 0.7
[3] Argentina Toba Rosario 0.6
[3] India Mumbai Marathas 0.6
[3] Spain Catalonia Girona 0.6
[3] Hong Kong Chinese 0.4
[3] Yuendumu (indig. Australia) 0.3
[3] Thailand Northeast 0.2

A32 is most common around the Persion Gulf and the Mediterranean Basin. It has a consistent presence in Europe. The A32 frequenceies in the more isolated (genetically) peoples of Europe suggests that the A32 rise in the mediterranean may only be partially attributable to recent migrations from the middle eastern region. There is a node in southern europe around the Ionian Sea in which specific, European, A32-haplotypes are elevated.

A32 Haplotypes

HLA A32 haplotype frequencies
freq
ref. Population (%)
A32-B7</br>(A*3201:B*0702)
Albanian 2.2
Cuban 1.9
[4] Natal Zulu (S. Africa) 1.0
Cretan 0.7
Cretan 0.2
A32-B8</br>(A*3201:B*0801)
N. Portugal 2.2
Oman 1.8
A32-B14</br>(A*3201:B*14)
!kung 1.9
Tunis 1.8
Natal Zulu (S. Africa) 1.0
Portugal 1.1
Irish 0.7
Italian 0.6
A32-B27</br>(A*3201:B27)
Gypsy(Spanish) 6.0
E Black Sea (Turkey) 2.3
German 0.3
A32-B35
(A*3201:C*0401:B*3501)
Greek 3.5
UA Emirates 2.8
Sardinian 2.6
Brahui (Pakistan) 2.5
Tunisia 1.8
Armenian 1.7
Italian 1.5
Oman 1.3
Portugal 1.1
German 0.3
A32-B61(40)
(A*3201:B*40)
Tunis 1.2
Greek 1.2
French 0.6
German 0.4
A32-B44
(A*3201:B*4402)
Austrian 2.4
Belgium 2.0
Albanian 1.8
S. Portugal 1.0
Irish 0.7
German 0.6
Dutch 0.6
Senegal 0.5
Italian 0.4
A32-B51</br>(A*3201:C*1201:B*5101)
Bulgarian 1.8
German 0.3
(A*3201:C*1502:B*5101)
Oman 5.0
Baloch (Pakistan) 3.2
Kalash 2.9
UA Emirates 1.9
Baloch (Iran) 1.1
(A*3201:C*1401:B*5101)
Parsis (Karachi) 4.9
Kalash 2.9

A common A32 haplotype A*3201-B*5101 can be found in Oman, United Arab Emirates, SE Iran, Bulgaria, and Portugal. A second, A*3201-B*3501 can be in the Omani, UAE, and Portugal.

References

  1. derived from IMGT/HLA
  2. Tang TF, Hou L, Tu B; et al. (2006). "Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries". Tissue Antigens. 68 (6): 518–20. PMID 17176443. doi:10.1111/j.1399-0039.2006.00707.x. 
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 3.48 3.49 3.50 3.51 3.52 3.53 3.54 3.55 3.56 3.57 3.58 3.59 3.60 3.61 3.62 3.63 3.64 3.65 3.66 3.67 3.68 3.69 3.70 3.71 3.72 3.73 3.74 3.75 3.76 3.77 3.78 3.79 3.80 3.81 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660.  External link in |title= (help)
  4. B*0705



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