HLA-A29

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major histocompatibility complex (human), class I, A29
Alleles A*2901 </br> A*2902 </br> A*2903
Structure (See HLA-A)
Identifiers
2901 2902 2903
Symbol(s) HLA-A
EBI-HLA A*2901
EBI-HLA A*2902
EBI-HLA A*2903
Shared data
Locus chr.6 6p21.31

HLA-A29 (A29) is an HLA-A serotype. The serotype identifies the more common HLA-A*29 gene products. A29 is a split antigen of the A19 broad antigen serotype group. It is similar to the antigens A30, A31, A32, A33, and A74. A31 is more common in Japan, Siberia and Indigenous Americans. It is also more frequent in NE Europe than SW Europe.


Serotype

A29 serotype recognition of Some HLA A*29 allele-group gene products[1]
A*29 A29 A19 Sample
allele  %  % size (N)
2901 96 119
2902 99 1148
2903 100 4


A29 Allele frequencies

A*2902

A29-B Haplotypes

HLA A31 haplotype frequencies
freq
ref. Population (%)
A29-Cw16-B44</br>(A*2902:Cw*1601:B*4403)
Basque, Gipuzkoa (Spain) 10.3
Basque, San Sebastion (Spain) 7.5
Pasiegos valley (Spain) 5.4
Basque, Arratia (Spain) 5.3
[2] Cornish (Gr. Britain) 5.3
[2] Spanish 5.0
Huate Corse (France) 4.3
Paris (France) 3.9
Portuguese 3.5
[2] French 3.4
Irish 3.4
S. African (Indig.) 2.7
N. Irish 2.8
[2] Dane 2.2
Tunisia 2.0
Wales 2.0
Tuscan 1.7
Dutch 1.4
German 1.3
Rainforest (Cameroon) 1.3

A29-Cw16-B44(A*2902:Cw*1601:B*4403) appears to have originated in West Africa were Cw*16 frequency is highest and had undergone more linkage equilibrium. Cw*16 decline slowly heading north and more rapidly to the east and northeast, with the highest frequency/latitude north generally along Eastern Spain into the British Ilses, some flow up the channel but haplotype frequency drops in the interior of Europe.

This haplotype can generally be extended from A- to -DQ as A29-Cw16-B44-DR7-DQ2.2:

A*2901 : Cw*1601 : B*4403 : DRB1*0701 : DQA1*0201 : DQB1*0202

And, the Cw16 component is in strong linkage disequilibrium with the DR7-DQ2.2 component suggesting that since the haplotypes introduction into Europe there has not been adequate time for equilibration, supporting its recent introduction into Europe. This particular haplotype supports theories of migration that are more numerous than those supported by mtDNA or Y chromosomal information, many such 'smaller' migrations are evident with HLA haplotypes, suggesting a much greater complexity to human population than haploid loci make evident.

References

  1. derived from IMGT/HLA
  2. 2.0 2.1 2.2 2.3 Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-262390-7. 



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