HLA-A26

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major histocompatibility complex (human), class I, A26
Alleles A*2601 </br> A*2602 </br> A*2603 </br> A*2605
Structure (See HLA-A)
Identifiers
2601 2602 2603 2605
Symbol(s) HLA-A
EBI-HLA A*2601
EBI-HLA A*2602
EBI-HLA A*2603
EBI-HLA A*2605
Shared data
Locus chr.6 6p21.31

HLA-A26 (A26) is an HLA-A serotype. The serotype identifies the more common HLA-A*26 gene products. A26 is a split antigen of the A10 broad antigen serotype group. A*2601 is believed to be the ancestral type for the A10 group, this group also includes A25, A34, A43 and A66.[1] A26 is broadly distributed but A26 is unusually common in Japan with a number of variants.


Serotype

A26 and A10 serotype recognition of Some HLA A*26 allele-group gene products[1]
A*26 A26 A10 Sample
allele  %  % size (N)
2601 97 2 1730
2602 81 31
2603 68 8 38
2605 90 10


Serotype recognition of most alleles is generally good.

Disease associations

A26 Serotype is associated with adult T-cell leukemia in Japanese.[2][3]

References

  1. derived from IMGT/HLA
  2. Nomura K, Utsunomiya A, Furushou H, Tara M, Hazeki M, Tokunaga M, Uozumi K, Hanada S, Yashiki S, Tajima K, Sonoda S (2006). "A family predisposition to adult T-cell leukemia.". J Clin Exp Hematop. 46 (2): 67–71. PMID 17142956. 
  3. Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K, Sonoda S (2001). "HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes.". AIDS Res Hum Retroviruses. 17 (11): 1047–61. PMID 11485622. 



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