HLA-A25

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major histocompatibility complex (human), class I, A25
Alleles A*2501 </br> A*2502
Structure (See HLA-A)
Identifiers
2501 2502
Symbol(s) HLA-A
EBI-HLA A*2501
EBI-HLA A*2502
Shared data
Locus chr.6 6p21.31

HLA-A25 (A25) is an HLA-A serotype. The serotype identifies the more common HLA-A*25 gene products. A25 is a split antigen of the A10 broad antigen serotype group. It is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A26 is more common in Western Europe.


Serotype

A25 and A10 serotype recognition of HLA A*2501 allele-group gene products[2]
A*25 A25 A10 Sample
allele  %  % size (N)
2501 95 2 1375
2502 80 5

There are 7 alleles for A25, 6 that result in different isoforms.

A25 frequencies

HLA A*2501 frequencies
freq
ref. Population (%)
[3] Saudi Arabia 5.7
[3] India Jalpaiguri Toto 5.2
[3] Russia Northwest 5.0
[3] Spain Pas Valley 4.3
[3] Czech Republic 4.2
[3] Spain North Cantabrian 4.2
[3] Russia Arkhangelsk Pomors 4.0
[3] Croatia 3.9
[3] Spain North Cabuernigo 3.8
[3] Russia Chuvash 3.7
[3] Romanian 3.5
[3] Italy Bergamo 3.2
[3] Croatia 3.0
[3] Israel Ashkenazi Jews 2.8
[3] Bulgaria 2.7
[3] Spain Basque Arratia Valley 2.7
[3] Sweden Uppsala County 2.6
[3] Ireland Northern 2.1
[3] Turkey 2.1
[3] Wales 2.1
[3] Spain Eastern Andalusia 2.0
[3] Georgia Svaneti Svans 1.9
[3] Italy 1.9
[3] England Manchester 1.9
[3] England Lancaster 1.8
[3] Jews (Israel) 1.7
[3] Macedonia 1.7
[3] England Sheffield 1.6
[3] Portugal South pop2 1.4
[3] Italy South Campania 1.2
[3] Uganda Kampala 1.2
[3] Finland 1.1
[3] Portugal North 1.1
[3] Belgium 1.0
[3] France Corsica 1.0
[3] Mongolia Oold 1.0
[3] Russia Murmansk Saomi 1.0
[3] Tunisia 1.0
[3] France South East 0.8
[3] Morocco Nador Metalsa 0.7
[3] Greece 0.6
[3] Italy North Pavia 0.6
[3] Algeria 0.5
[3] China Qinghai Hui 0.5
[3] Guatemala Mayans 0.4
[3] Russia Nenets 0.4
[3] Cameroon Beti 0.3
[3] Beijing Shijiazhuang 0.1
[3] Taiwan Hakka 0.1

A*2501 distribution is primarily located in western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

References

  1. Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. PMID 8475492. 
  2. derived from IMGT/HLA
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 3.48 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660.  External link in |title= (help)



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