H4 receptor

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histamine receptor H4
Identifiers
SymbolHRH4
Entrez59340
HUGO17383
OMIM606792
RefSeqNM_021624
UniProtQ9H3N8
Other data
LocusChr. 18 q11.2

The H4 histamine receptor was first published by Nguyen et al in March of 2001, who also published the gene encoded it in a search of the GenBank databases.[1] Like the other three histamine receptors, it is also a G protein-coupled receptor.

Location

H4 is highly expressed in bone marrow and white blood cells and regulates zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model along with L-selectin.[2] It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea.[3]

Functions

They have been shown to mediate mast cell chemotaxis.[4] ...and more

High affinity substances

The following substances have been found to bind with high affinity to this receptor:

Moderate affinity substances

The following substances have been found to bind with moderate affinity to this receptor:

Weak affinity substances

The following substances have been found to bind with weak affinity to this receptor:

References

  1. Tuan Nguyen, David A. Shapiro, Susan R. George, Vincent Setola, Dennis K. Lee, Regina Cheng, Laura Rauser, Samuel P. Lee, Kevin R. Lynch, Bryan L. Roth, and Brian F. O'Dowd Discovery of a Novel Member of the Histamine Receptor Family The Journal of Molecular Pharmacology Vol. 59, Issue 3, 427-433, March 2001
  2. Takeshita, Keisuke (2004). "Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan". The Journal of Pharmacology and Experimental Therapeutics. 310 (1): 272–80. doi:10.1124/jpet.103.063776. PMID 14996947. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)
  3. Bioreagents.com: Histamine H4 Receptor
  4. Hofstra, Claudia L. (2003). "Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells". Journal of Pharmacology And Experimental Therapeutics. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656. Unknown parameter |coauthors= ignored (help); Unknown parameter |month= ignored (help)

External links





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