Guanylate kinase

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In enzymology, a guanylate kinase (EC 2.7.4.8) is an enzyme that catalyzes the chemical reaction

ATP + GMP ADP + GDP

Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(d)GMP phosphotransferase. Other names in common use include deoxyguanylate kinase, 5'-GMP kinase, GMP kinase, guanosine monophosphate kinase, and ATP:GMP phosphotransferase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1EX6, 1EX7, 1GKY, 1LVG, 1S4Q, 1S96, 1Z6G, 1Z8F, 1ZNW, 1ZNX, 1ZNY, 1ZNZ, 2AN9, 2ANB, 2ANC, 2F3R, 2F3T, 2J41, and 2QOR.

References

  • IUBMB entry for 2.7.4.8
  • BRENDA references for 2.7.4.8 (Recommended.)
  • PubMed references for 2.7.4.8
  • PubMed Central references for 2.7.4.8
  • Google Scholar references for 2.7.4.8
  • Buccino RJ Jr, Roth JS (1969). "Partial purification and properties of ATP:GMP phosphransferase from rat liver". Arch. Biochem. Biophys. 132: 49&ndash, 61. PMID 4307347.
  • Hiraga S, Sugino Y (1966). "Nucleoside monophosphokinases of Escherichia coli infected and uninfected with an RNA phage". Biochim. Biophys. Acta. 114: 416&ndash, 8. PMID 5329274.
  • Griffith TJ, Helleiner CW (1965). "The partial purification of deoxynucleoside monophosphate kinases from L cells". Biochim. Biophys. Acta. 108: 114&ndash, 24. PMID 5862227.
  • Oeschger MP, Bessman MJ (1966). "Purification and properties of guanylate kinase from Escherichia coli". J. Biol. Chem. 241: 5452&ndash, 60. PMID 5333666.
  • Shimono H, Sugino Y (1971). "Metabolism of deoxyribonucleotides. Purification and properties of deoxyguanosine monophosphokinase of calf thymus". Eur. J. Biochem. 19: 256&ndash, 63. PMID 5552394.

External links

The CAS registry number for this enzyme class is 9026-59-9.

Gene Ontology (GO) codes


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