Granulocyte macrophage colony-stimulating factor receptor

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colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Identifiers
SymbolCSF2RA
Alt. symbolsCSF2R
Entrez1438
HUGO2435
OMIM425000
RefSeqNM_172248
UniProtP15509
Other data
LocusChr. Y p11

The granulocyte macrophage colony-stimulating factor receptor is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[1].

Structure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[3]

Signal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway. [4]

References

  1. N.A. Nicola,D. Metcalf. (1985). Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells. J Cell Physiol. 124:313
  2. B.J. McClure, T.R. Hercus, B.A. Cambareri, J.M. Woodcock, C.J. Bagley. G.J. Howlett, and A.F. Lopez (2003) Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex Blood Vol 101, No. 4
  3. 3.0 3.1 N. Geijsena, L. Koendermana and P.J. Coffer (2001) Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine & Growth Factor Reviews Vol 12 Issue 1 Pages 19-25
  4. S.E. Doyle and J.C. Gasson (1998) Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5 Blood Vol 92 No 3 pp 867-876

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