Gonadoblastoma

Jump to: navigation, search

WikiDoc Resources for Gonadoblastoma

Articles

Most recent articles on Gonadoblastoma

Most cited articles on Gonadoblastoma

Review articles on Gonadoblastoma

Articles on Gonadoblastoma in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Gonadoblastoma

Images of Gonadoblastoma

Photos of Gonadoblastoma

Podcasts & MP3s on Gonadoblastoma

Videos on Gonadoblastoma

Evidence Based Medicine

Cochrane Collaboration on Gonadoblastoma

Bandolier on Gonadoblastoma

TRIP on Gonadoblastoma

Clinical Trials

Ongoing Trials on Gonadoblastoma at Clinical Trials.gov

Trial results on Gonadoblastoma

Clinical Trials on Gonadoblastoma at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Gonadoblastoma

NICE Guidance on Gonadoblastoma

NHS PRODIGY Guidance

FDA on Gonadoblastoma

CDC on Gonadoblastoma

Books

Books on Gonadoblastoma

News

Gonadoblastoma in the news

Be alerted to news on Gonadoblastoma

News trends on Gonadoblastoma

Commentary

Blogs on Gonadoblastoma

Definitions

Definitions of Gonadoblastoma

Patient Resources / Community

Patient resources on Gonadoblastoma

Discussion groups on Gonadoblastoma

Patient Handouts on Gonadoblastoma

Directions to Hospitals Treating Gonadoblastoma

Risk calculators and risk factors for Gonadoblastoma

Healthcare Provider Resources

Symptoms of Gonadoblastoma

Causes & Risk Factors for Gonadoblastoma

Diagnostic studies for Gonadoblastoma

Treatment of Gonadoblastoma

Continuing Medical Education (CME)

CME Programs on Gonadoblastoma

International

Gonadoblastoma en Espanol

Gonadoblastoma en Francais

Business

Gonadoblastoma in the Marketplace

Patents on Gonadoblastoma

Experimental / Informatics

List of terms related to Gonadoblastoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Synonyms and Keywords: Gonadoblastomas; Gonadoblastomata

Overview

Gonadoblastoma was first discovered by Scully, in 1953. A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells. Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy. Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as 17-hydroxylase deficiency syndrome, 5-alpha-reductase deficiency, amenorrhea, congenital adrenal hyperplasia, hypospadias, and Meigs syndrome. Gonadoblastoma may also be diagnosed using chromosomal analysis. Surgery is the mainstay of therapy for gonadoblastoma.

Historical Perspective

  • Gonadoblastoma was first discovered by Scully, in 1953.

Pathophysiology

Causes

  • Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.

Differentiating Gonadoblastoma from other Diseases

  • Gonadoblastoma must be differentiated from other diseases such as:
  • 17-Hydroxylase Deficiency Syndrome
  • 5-Alpha-Reductase Deficiency
  • Amenorrhea
  • Congenital Adrenal Hyperplasia
  • Genital Anomalies
  • Hypospadias
  • Pediatric Seminoma
  • Turner Syndrome
  • Meigs syndrome

Other Diagnostic Studies

  • Gonadoblastoma may also be diagnosed using chromosomal analysis.

Treatment

Surgery

  • Surgery is the mainstay of therapy for gonadoblastoma.
  • Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.

References

  1. Gonadoblstoma. Wikipedia (2016). https://en.wikipedia.org/wiki/Gonadoblastoma Accessed on April 15, 2016

Linked-in.jpg