Glycochenodeoxycholate sulfotransferase

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In enzymology, a glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + glycochenodeoxycholate adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and glycochenodeoxycholate, whereas its two products are adenosine 3',5'-bisphosphate and glycochenodeoxycholate 7-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.

References

  • IUBMB entry for 2.8.2.34
  • BRENDA references for 2.8.2.34 (Recommended.)
  • PubMed references for 2.8.2.34
  • PubMed Central references for 2.8.2.34
  • Google Scholar references for 2.8.2.34
  • BI (1979). "Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". J. Lipid. Res. 20: 952&ndash, 9. PMID 533830.
  • Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137&ndash, 74. PMID 12543708.

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