Glutamate 5-kinase

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In enzymology, a glutamate 5-kinase (EC 2.7.2.11) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate ADP + L-glutamate 5-phosphate

Thus, the two substrates of this enzyme are ATP and L-glutamate, whereas its two products are ADP and L-glutamate 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:L-glutamate 5-phosphotransferase. Other names in common use include ATP-L-glutamate 5-phosphotransferase, ATP:gamma-L-glutamate phosphotransferase, gamma-glutamate kinase, gamma-glutamyl kinase, and glutamate kinase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2AKO, 2J5T, and 2J5V.

References

  • IUBMB entry for 2.7.2.11
  • BRENDA references for 2.7.2.11 (Recommended.)
  • PubMed references for 2.7.2.11
  • PubMed Central references for 2.7.2.11
  • Google Scholar references for 2.7.2.11
  • Baich A (1969). "Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase". Biochim. Biophys. Acta. 192: 462&ndash, 7. PMID 4904678.

External links

The CAS registry number for this enzyme class is 54596-30-4.

Gene Ontology (GO) codes


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