Glucose isomerase

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Glucose phosphate isomerase
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Enzyme Phosphoglucose isomerase
PDB Code PDB: 1GZV
Organism Pig
Tissue Muscle
Complexed molecules 5-phosphoarabinoate
Symbol(s): GPI
Genetic data
Locus: Chr. 19 q13.1
Database Links
EC number: 5.3.1.9
Entrez: 2821
OMIM: 172400
RefSeq: NM_000175
UniProt: P06744

Phosphoglucose isomerase is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. An unrelated enzyme, D-xylose isomerase (EC 5.3.1.5) catalyzes the isomerization of glucose to fructose, and is sometimes called "glucose isomerase".

In glycolysis

α-D-Glucose 6-phosphate {{{forward_enzyme}}} β-D-Fructose 6-phosphate
Glucose-6-phosphate wpmp.png   Fructose-6-phosphate wpmp.png
{{{minor_forward_substrate(s)}}} {{{minor_forward_product(s)}}}
[[image:Biochem_reaction_arrow_{{{reaction_direction_(forward/reversible/reverse)}}}_NNNN_horiz_med.svg|75px]]
 
  Phosphoglucose isomerase


As a glucose isomerase

D-Glucose {{{forward_enzyme}}} D-Fructose
D-glucose wpmp.png   File:D-fructose wpmp.png
{{{minor_forward_substrate(s)}}} {{{minor_forward_product(s)}}}
[[image:Biochem_reaction_arrow_{{{reaction_direction_(forward/reversible/reverse)}}}_NNNN_horiz_med.svg|75px]]
 
  Phosphoglucose isomerase


Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.


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