GlmS glucosamine-6-phosphate activated ribozyme
Glucosamine-6-phosphate activated ribozyme is found in the mRNA for GlmS. GlmS is an enzyme that uses fructose-6-phosphate and glutamine to generate glucosamine-6-phosphate. The ribozyme catalyses self cleavage of the glmS mRNA thereby regulating GlmS activity . The GlmS element is only catalytic when bound to glucosamine-6-phosphate. The glucosamine-6-phosphate is a cofactor for the catalytic reaction, directly participating in the chemistry. This is the only known case of a ribozyme using a small-molecule cofactor at present.
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- Cochrane JC, Lipchock SV, Strobel SA (2007). "Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor". Chem. Biol. 14 (1): 97–105. doi:10.1016/j.chembiol.2006.12.005. PMID 17196404.
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- Hampel, KJ (2006). "Evidence for preorganization of the glmS ribozyme ligand binding pocket". Biochemistry. 45: 7861&ndash, 7871. PMID 16784238. Unknown parameter
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