Glia maturation factor is a neurotrophic factor implicated in nervous system development, angiogenesis and immune function.
The structures of mouse glia maturation factors beta and gamma, solved by both crystallography and NMR, reveal similarities and critical differences with ADF-H (actin depolymerization factor homology) domains and suggest new means of experimentally addressing the function of this protein family.
Stereo ribbon diagram of the crystal structure of GMFG. Spectral coloring is from blue (N-terminus) to red (C-terminus). Secondary structural elements are indicated