Generalized anxiety disorder pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Irfan Dotani


Generalized anxiety disorder has been linked to the disrupted functional connectivity of the amygdala and its processing of fear and anxiety. Sensory information enters the amygdala through the nuclei of the basolateral complex (consisting of lateral, basal and accessory basal nuclei).



  1. Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD (2009). "Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder". Arch Gen Psychiatry. 66 (12): 1361–72. doi:10.1001/archgenpsychiatry.2009.104. PMID 19996041.
  2. Kessler RC, Keller MB, Wittchen HU (2001). "The epidemiology of generalized anxiety disorder". Psychiatr Clin North Am. 24 (1): 19–39. PMID 11225507.
  3. Baldwin DS, Allgulander C, Bandelow B, Ferre F, Pallanti S (2012). "An international survey of reported prescribing practice in the treatment of patients with generalised anxiety disorder". World J Biol Psychiatry. 13 (7): 510–6. doi:10.3109/15622975.2011.624548. PMID 22059936.
  4. Grant BF, Hasin DS, Stinson FS, Dawson DA, June Ruan W, Goldstein RB; et al. (2005). "Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions". Psychol Med. 35 (12): 1747–59. doi:10.1017/S0033291705006069. PMID 16202187.