GPR6

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]

See also

References

  1. "Entrez Gene: GPR6 G protein-coupled receptor 6".
  2. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
  3. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  4. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443.

Further reading

External links

  • "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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