GPR182

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External IDsGeneCards: [1]
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GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.[1]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.[2] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).[3]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.[4]

References

  1. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  2. Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID 9367907.
  3. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID 9535752.
  4. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. doi:10.1038/30666. PMID 9620797.

Further reading

External links

  • "GPR182". IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. Retrieved 2008-07-03.

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