Aquaporin 3

(Redirected from GIL antigen system)
Jump to: navigation, search

Template:Infobox gene

Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells.[1] In the kidney, AQP3 is regulated by vasopressin (ADH).[2] This protein is also a determinant for the GIL blood group system.[3]

Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[4]

Clinical significance

AQP3 levels are often lower in psoriasis than in healthy skin.[4]

AQP3 is expressed more in atopic eczema.[5]

See also


  1. Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. PMID 9558461. doi:10.1146/annurev.physiol.60.1.199. 
  2. Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (4 ed.): 346 – via Elsevier. 
  3. Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. PMID 12239222. doi:10.1074/jbc.M208999200. 
  4. 4.0 4.1 Cancer therapy shows promise for psoriasis treatment
  5. Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema.". Allergy. 61 (9): 1132–7. PMID 16918518. doi:10.1111/j.1398-9995.2006.01151.x. 

Further reading


External links