G12/G13 alpha subunits

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guanine nucleotide-binding protein (G protein) alpha 12
Identifiers
SymbolGNA12
Entrez2768
HUGO4380
OMIM604394
RefSeqNM_007353
UniProtQ03113
Other data
LocusChr. 7 p22.3
guanine nucleotide-binding protein (G protein), alpha 13
Identifiers
SymbolGNA13
Entrez10672
HUGO4381
OMIM604406
RefSeqNM_006572
UniProtQ14344
Other data
LocusChr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors.[1] These two subunits represent a fourth class of G protein alpha subunits.[2] They are not sensitive to pertussis toxin.[3]

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.[4] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.[5]

Genes

References

  1. Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523.
  2. Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. doi:10.1073/pnas.88.13.5582. PMC 51921. PMID 1905812.
  3. Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319. ( Pt 1): 165–71. PMC 1217750. PMID 8870664.
  4. Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J. Biol. Chem. 281 (43): 32660–7. doi:10.1074/jbc.M604588200. PMID 16943201.
  5. Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell. 10 (6): 707–18. doi:10.1016/j.devcel.2006.03.014. PMID 16740474.

External links


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