Flufenamic acid

Jump to: navigation, search

{{Drugbox | Watchedfields = changed | verifiedrevid = 443821617 | IUPAC_name = 2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid | image = flufenamic acid.png | image2 = Flufenamic acid0.png

| tradename = | Drugs.com = International Drug Names | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = S4 | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = oral, topical

| bioavailability = | protein_bound = extensively | metabolism = Hydroxylation, glucuronidation | elimination_half-life = ~3 h | excretion = 50% urine, 36% feces

| CASNo_Ref =  ☑Y | CAS_number_Ref =  ☑Y | CAS_number = 530-78-9 | ATC_prefix = M01 | ATC_suffix = AG03 | PubChem = 3371 | IUPHAR_ligand = 2447 | DrugBank_Ref =  ☑Y | DrugBank = DB02266 | ChemSpiderID_Ref =  ☑Y | ChemSpiderID = 3254 | UNII_Ref =  ☑Y | UNII = 60GCX7Y6BH | KEGG_Ref =  ☑Y | KEGG = D01581 | ChEBI_Ref =  ☑Y | ChEBI = 42638 | ChEMBL_Ref =  ☑Y | ChEMBL = 23588

| C=14 | H=10 | F=3 | N=1 | O=2 | molecular_weight = 281.22991 g/mol | smiles = FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)O | InChI = 1/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) | InChIKey = LPEPZBJOKDYZAD-UHFFFAOYAI | StdInChI_Ref =  ☑Y | StdInChI = 1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) | StdInChIKey_Ref =  ☑Y | StdInChIKey = LPEPZBJOKDYZAD-UHFFFAOYSA-N | melting_point = 124 | melting_high = 125 | melting_notes = resolidification and remelting at 134°C to 136°C | solubility = Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether }}

WikiDoc Resources for Flufenamic acid

Articles

Most recent articles on Flufenamic acid

Most cited articles on Flufenamic acid

Review articles on Flufenamic acid

Articles on Flufenamic acid in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Flufenamic acid

Images of Flufenamic acid

Photos of Flufenamic acid

Podcasts & MP3s on Flufenamic acid

Videos on Flufenamic acid

Evidence Based Medicine

Cochrane Collaboration on Flufenamic acid

Bandolier on Flufenamic acid

TRIP on Flufenamic acid

Clinical Trials

Ongoing Trials on Flufenamic acid at Clinical Trials.gov

Trial results on Flufenamic acid

Clinical Trials on Flufenamic acid at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Flufenamic acid

NICE Guidance on Flufenamic acid

NHS PRODIGY Guidance

FDA on Flufenamic acid

CDC on Flufenamic acid

Books

Books on Flufenamic acid

News

Flufenamic acid in the news

Be alerted to news on Flufenamic acid

News trends on Flufenamic acid

Commentary

Blogs on Flufenamic acid

Definitions

Definitions of Flufenamic acid

Patient Resources / Community

Patient resources on Flufenamic acid

Discussion groups on Flufenamic acid

Patient Handouts on Flufenamic acid

Directions to Hospitals Treating Flufenamic acid

Risk calculators and risk factors for Flufenamic acid

Healthcare Provider Resources

Symptoms of Flufenamic acid

Causes & Risk Factors for Flufenamic acid

Diagnostic studies for Flufenamic acid

Treatment of Flufenamic acid

Continuing Medical Education (CME)

CME Programs on Flufenamic acid

International

Flufenamic acid en Espanol

Flufenamic acid en Francais

Business

Flufenamic acid in the Marketplace

Patents on Flufenamic acid

Experimental / Informatics

List of terms related to Flufenamic acid

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Flufenamic acid, also known as Fluffy or Fluf, is a non-steroidal anti-inflammatory drug.It is pale yellow crystalline powder. In humans, flufenamic acid acts in part by binding to and reducing the activity of prostaglandin F synthase and activating TRPC6, a property it shares with the anti-inflammatory herb St Johns Wort.

Flufenamic acid also blocks voltage-gated sodium channels responsible for the depolarising after-potential (DAP) that underlies phasic firing in the phasic firing of magnocellular neurons in the supraoptic and paraventricular nuclei.

References


Linked-in.jpg