Jump to: navigation, search

WikiDoc Resources for Flagellin


Most recent articles on Flagellin

Most cited articles on Flagellin

Review articles on Flagellin

Articles on Flagellin in N Eng J Med, Lancet, BMJ


Powerpoint slides on Flagellin

Images of Flagellin

Photos of Flagellin

Podcasts & MP3s on Flagellin

Videos on Flagellin

Evidence Based Medicine

Cochrane Collaboration on Flagellin

Bandolier on Flagellin

TRIP on Flagellin

Clinical Trials

Ongoing Trials on Flagellin at Clinical Trials.gov

Trial results on Flagellin

Clinical Trials on Flagellin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Flagellin

NICE Guidance on Flagellin


FDA on Flagellin

CDC on Flagellin


Books on Flagellin


Flagellin in the news

Be alerted to news on Flagellin

News trends on Flagellin


Blogs on Flagellin


Definitions of Flagellin

Patient Resources / Community

Patient resources on Flagellin

Discussion groups on Flagellin

Patient Handouts on Flagellin

Directions to Hospitals Treating Flagellin

Risk calculators and risk factors for Flagellin

Healthcare Provider Resources

Symptoms of Flagellin

Causes & Risk Factors for Flagellin

Diagnostic studies for Flagellin

Treatment of Flagellin

Continuing Medical Education (CME)

CME Programs on Flagellin


Flagellin en Espanol

Flagellin en Francais


Flagellin in the Marketplace

Patents on Flagellin

Experimental / Informatics

List of terms related to Flagellin

Helicobacter pylori electron micrograph, showing multiple flagella on the cell surface

Flagellin is a protein that arranges itself in a hollow cylinder to form the filament in bacterial flagellum. It has a mass of about 30,000 to 60,000 daltons. Flagellin is the principal substituent of bacterial flagellum, and is present in large amounts on nearly all flagellated bacteria.


The structure of flagellin is responsible for the helical shape of the flagellar filament, which is important for its proper function.

The N- and C-termini of flagellin form the inner core of the flagellin protein, and is responsible for flagellin's ability to polymerize into a filament. The central portion of the protein makes up the outer surface of the flagellar filament. While the termini of the protein is quite similar between all bacterial flagellins, the central portion is wildly variable.

Immune response

In mammals

Mammals often have acquired immune responses (T-cell and antibody responses) to flagellated bacterium occurs frequently to flagellar antigens. Some bacteria are able to switch between multiple flagellin genes in order to evade this response.

The propensity of the immune response to flagellin may be explained by two facts:

  • First, flagellin is an extremely abundant protein in flagellated bacteria.
  • Secondly, there exists a specific innate immune receptor that recognizes flagellin, Toll-like receptor 5 (TLR5).

In plants

In addition a 22 amino acid sequence (flg22) of the conserved N-terminal part of flagellin is known to activate plant defence mechanisms. Flagellin perception in Arabidopsis thaliana functions via the receptor-like-kinase, FLS2 (flagellin-sensitive-2)). Mitogen-activated-protein-kinases (MAPK) acts as signalling compounds and more than 900 genes are affected upon flg22 treatment.

Pre-stimulation with a synthetic flg22-peptide led to enhanced resistance against bacterial invaders.

External links

More detailed information: Research article: bacterial flagellin and plant disease resistance, published by Zipfel. et al (2004) ) Abstract Article