Fibrocystin

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Fibrocystin
Identifiers
SymbolFibrocystin
InterProIPR029927
Membranome632
polycystic kidney and hepatic disease 1 (autosomal recessive)
Identifiers
SymbolPKHD1
Alt. symbolsTIGM1
Entrez5314
HUGO9016
OMIM606702
RefSeqNM_138694
UniProtQ8TCZ9
Other data
LocusChr. 6 p21.2-p12

Fibrocystin is a large, receptor-like protein that is thought to be involved in the tubulogenesis and/or maintenance of duct-lumen architecture of epithelium.[1] FPC associates with the primary cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular pathway.

Pathology

Mutations of its encoding gene (chromosomal locus 6p12.2) can cause autosomal recessive polycystic kidney disease.

References

  1. Zhang M, Mai W, Li C, Cho S, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris R, Li S, Coffey R, Sun L, Wu D, Chen X, Breyer M, Zhao Z, McKanna J, Wu G (2004). "PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells". Proc Natl Acad Sci USA. 101 (8): 2311–6. doi:10.1073/pnas.0400073101. PMC 356947. PMID 14983006.

External links


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