Fatty acid-binding protein
The fatty-acid-binding proteins (FABPs) are a family of carrier proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR.
Members of this family inlcude:
- FABP 1, liver (FABP1)
- FABP 2, intestinal (FABP2)
- FABP 3, muscle and heart (mammary-derived growth inhibitor) (FABP3)
- FABP 4, adipocyte (FABP4)
- FABP 5 (psoriasis-associated) (FABP5)
- FABP 5-like 1 (FABP5L1)
- FABP 5-like 2 (FABP5L2)
- FABP 5-like 3 (FABP5L3)
- FABP 5-like 4 (FABP5L4)
- FABP 5-like 5 (FABP5L5)
- FABP 5-like 6 (FABP5L6)
- FABP 5-like 7 (FABP5L7)
- FABP 6, ileal (gastrotropin) (FABP6)
- FABP 7, brain (FABP7)
- FABP 8, peripheral myelin protein 2 (PMP2)
- FABP 9, testis (FABP9)
- Chmurzyńska A (2006). "The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism". J. Appl. Genet. 47 (1): 39–48. PMID 16424607.
- Weisiger RA (2002). "Cytosolic fatty acid binding proteins catalyze two distinct steps in intracellular transport of their ligands". Mol. Cell. Biochem. 239 (1–2): 35–43. doi:10.1023/A:1020550405578. PMID 12479566.
- Tan NS, Shaw NS, Vinckenbosch N, Liu P, Yasmin R, Desvergne B, Wahli W, Noy N (2002). "Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription". Mol. Cell. Biol. 22 (14): 5114–27. doi:10.1128/MCB.22.14.5114-5127.2002. PMID 12077340.
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