Fatty-acid synthase

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In enzymology, a fatty-acid synthase (EC is an enzyme that catalyzes the chemical reaction

acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H+, whereas its 4 products are long-chain fatty acid, CoA, CO2, and NADP+.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing). This enzyme is also called yeast fatty acid synthase. This enzyme participates in fatty acid biosynthesis and insulin signaling pathway.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1N8L, 2CF2, 2CG5, 2JFD, 2JFK, 2PNG, and 2PX6.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM (1979). "Physicochemical studies of the rat liver and adipose fatty acid synthetases". J. Biol. Chem. 254: 7418&ndash, 26. PMID 457689.
  • Wakil SJ, Stoops JK, Joshi VC (1983). "Fatty acid synthesis and its regulation". Annu. Rev. Biochem. 52: 537&ndash, 79. PMID 6137188.

External links

The CAS registry number for this enzyme class is 9045-77-6.

Gene Ontology (GO) codes