Fanconi syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vahid Eidkhani, M.D.


Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT); in a simple and useful classification method, the causes could be classified as[1][2]:


Genetic Causes[1][2]

Exogenous causes[1][3]

Acquired causes[2][1][4]

Less Common Causes

Less common causes of Fanconi syndrome mostly found on case reports include:

  • Other drugs such as: Fumaric Acid, Ranitidine, Salicylate, Methyl-3-Chromone in high doses and for long periods
  • Chronic Alcohol abuse
  • Crude Chinese herbal drugs (sometimes called Boui-ougi-tou)
  • L-Lysine
  • Glue Sniffing
  • Autosomal dominant Fanconi syndrome with macrosomia and young-onset diabetes mellitus
  • Arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome
  • Idiopathic Fanconi syndrome

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

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  1. 1.0 1.1 1.2 1.3 Haque SK, Ariceta G, Batlle D (2012). "Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies". Nephrol Dial Transplant. 27 (12): 4273–87. doi:10.1093/ndt/gfs493. PMC 3616759. PMID 23235953.
  2. 2.0 2.1 2.2 Enriko Klootwijk, Stephanie Dufek, Naomi Issler, Detlef Bockenhauer & Robert Kleta (2016)Pathophysiology, current treatments and future targets in hereditary forms of renal Fanconi syndrome,Expert Opinion on Orphan Drugs, 5:1, 45-54, DOI: 10.1080/21678707.2017.1259560
  3. Izzedine H, Launay-Vacher V, Isnard-Bagnis C, Deray G (2003). "Drug-induced Fanconi's syndrome". Am J Kidney Dis. 41 (2): 292–309. doi:10.1053/ajkd.2003.50037. PMID 12552490.
  4. Ria R, Dammacco F, Vacca A (2018). "Heavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update". Mediterr J Hematol Infect Dis. 10 (1): e2018011. doi:10.4084/MJHID.2018.011. PMC 5760076. PMID 29326807.