Familial amyloidosis natural history, complications and prognosis

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Familial amyloidosis Microchapters


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Differentiating Familial amyloidosis from other Diseases

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Natural History, Complications and Prognosis


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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.


The symptoms of familial amyloidosis usually develop after 50 years of age in TTR amyloidosis and late adulthood for other subtypes. In patients with familial amyloidosis, the most frequent complications include heart failure, nephrotic syndrome, hepatomegaly, and peripheral neuropathy. Prognosis is generally poor. The prognosis varies based on the type of organ involvement with amyloid heart disease having the worst prognosis. TTR amyloidosis patients have 60 months survival from presentation with heart failure symptoms.

Natural History, Complications, and Prognosis

Natural History




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