Factor XIII deficiency

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Factor XIII deficiency
ICD-10 D68.2
ICD-9 286.3
OMIM 134570 134580
DiseasesDB 31412
MeSH D005177

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Factor XIII deficiency may occur very rarely, and can cause a severe bleeding tendency. Incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit. Administration of recombinant A subunit improves clot stability and may become a therapeutic option for patients with this condition[1].

See also

References

  1. Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, Blain R, Pederson S, Ishak L, Nugent D (2006). "Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency.". Blood. 108 (1): 57–62. PMID 16556896. 

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