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RefSeq (mRNA)



RefSeq (protein)



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FUN14 domain containing 1 is a protein that in humans is encoded by the FUNDC1 gene.[1]

Model organisms

Model organisms have been used in the study of FUNDC1 function. A conditional knockout mouse line, called Fundc1tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty two tests were carried out on mutant mice, however no significant abnormalities were observed.[4]


  1. "Entrez Gene: FUN14 domain containing 1". Retrieved 2011-09-19.
  2. "Salmonella infection data for Fundc1". Wellcome Trust Sanger Institute.
  3. "Citrobacter infection data for Fundc1". Wellcome Trust Sanger Institute.
  4. 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. "International Knockout Mouse Consortium".
  7. "Mouse Genome Informatics".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

Terracciano, A.; Sanna, S.; Uda, M.; Deiana, B.; Usala, G.; Busonero, F.; Maschio, A.; Scally, M.; Patriciu, N.; Chen, W. -M.; Distel, M. A.; Slagboom, E. P.; Boomsma, D. I.; Villafuerte, S.; Sliwerska, E.; Burmeister, M.; Amin, N.; Janssens, A. C. J. W.; Van Duijn, C. M.; Schlessinger, D.; Abecasis, G. R.; Costa Jr, P. T. (2008). "Genome-wide association scan for five major dimensions of personality". Molecular Psychiatry. 15 (6): 647–656. doi:10.1038/mp.2008.113. PMC 2874623. PMID 18957941.