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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
PubMed searchn/an/a
View/Edit Human

FERM domain-containing protein 6 is a protein that in humans is encoded by the FRMD6 gene.[1]


  1. "Entrez Gene: FRMD6 FERM domain containing 6".

Further reading

  • Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ (2013). "Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts". PLOS ONE. 8 (4): e60028. doi:10.1371/journal.pone.0060028. PMC 3620498. PMID 23593160.
  • Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ (January 2012). "Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP". Oncogene. 31 (2): 238–50. doi:10.1038/onc.2011.224. PMID 21666719.
  • Madan R, Brandwein-Gensler M, Schlecht NF, Elias K, Gorbovitsky E, Belbin TJ, Mahmood R, Breining D, Qian H, Childs G, Locker J, Smith R, Haigentz M, Gunn-Moore F, Prystowsky MB (November 2006). "Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic significance for head and neck squamous cell carcinoma". Head & Neck. 28 (11): 1018–27. doi:10.1002/hed.20435. PMID 16783828.
  • Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (January 2006). "The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis". Nature Cell Biology. 8 (1): 27–36. doi:10.1038/ncb1339. PMID 16341207.
  • Gunn-Moore FJ, Welsh GI, Herron LR, Brannigan F, Venkateswarlu K, Gillespie S, Brandwein-Gensler M, Madan R, Tavaré JM, Brophy PJ, Prystowsky MB, Guild S (September 2005). "A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'". FEBS Letters. 579 (22): 5089–94. doi:10.1016/j.febslet.2005.07.097. PMID 16137681.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.