FLT1

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Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
PBB Protein FLT1 image.jpg
PDB rendering based on 1flt.
Identifiers
Symbols FLT1 ; FLT; VEGFR1
External IDs OMIM: 165070 MGI95558 HomoloGene20463
RNA expression pattern
PBB GE FLT1 222033 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 2321
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 14254

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000102755
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000029648

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P17948
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q9CSC8

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002019 (mRNA)
NP_002010 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_010228 (mRNA)
NP_034358 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 13: 27.77 - 27.97 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 5: 147.87 -  148.04 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

WikiDoc Resources for FLT1

Articles

Most recent articles on FLT1

Most cited articles on FLT1

Review articles on FLT1

Articles on FLT1 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on FLT1

Images of FLT1

Photos of FLT1

Podcasts & MP3s on FLT1

Videos on FLT1

Evidence Based Medicine

Cochrane Collaboration on FLT1

Bandolier on FLT1

TRIP on FLT1

Clinical Trials

Ongoing Trials on FLT1 at Clinical Trials.gov

Trial results on FLT1

Clinical Trials on FLT1 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on FLT1

NICE Guidance on FLT1

NHS PRODIGY Guidance

FDA on FLT1

CDC on FLT1

Books

Books on FLT1

News

FLT1 in the news

Be alerted to news on FLT1

News trends on FLT1

Commentary

Blogs on FLT1

Definitions

Definitions of FLT1

Patient Resources / Community

Patient resources on FLT1

Discussion groups on FLT1

Patient Handouts on FLT1

Directions to Hospitals Treating FLT1

Risk calculators and risk factors for FLT1

Healthcare Provider Resources

Symptoms of FLT1

Causes & Risk Factors for FLT1

Diagnostic studies for FLT1

Treatment of FLT1

Continuing Medical Education (CME)

CME Programs on FLT1

International

FLT1 en Espanol

FLT1 en Francais

Business

FLT1 in the Marketplace

Patents on FLT1

Experimental / Informatics

List of terms related to FLT1


Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1, is a human gene.

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM][1]

See also

References

  1. "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)".

Further reading

  • Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
  • Sato Y, Kanno S, Oda N; et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Ann. N. Y. Acad. Sci. 902: 201–5, discussion 205–7. PMID 10865839.
  • Boyd AW, Lackmann M (2002). "Signals from Eph and ephrin proteins: a developmental tool kit". Sci. STKE. 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
  • Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Ann. N. Y. Acad. Sci. 979: 80–93. PMID 12543719.
  • Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatr. Res. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
  • Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis. 9 (4): 225–30, discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
  • Widmer M, Villar J, Benigni A; et al. (2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and gynecology. 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
  • López-Novoa JM (2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrol. Dial. Transplant. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.





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