FGR (gene)

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]

Function

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

Discovery

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]

Interactions

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]

References

  1. Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
  2. 2.0 2.1 "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
  3. Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
  4. Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332.
  5. Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280.
  6. Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. PMC 230823. PMID 7565724.

Further reading



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