Extraction ratio

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Extraction ratio is a measure in renal physiology, primarily used to calculate renal plasma flow in order to evaluate renal function. It is the amount of compound entering the kidney that got excreted into the final urine. [1].

Measured in concentration in blood plasma, it may thus be expressed as:

Failed to parse (MathML with SVG or PNG fallback (recommended for modern browsers and accessibility tools): Invalid response ("Math extension cannot connect to Restbase.") from server "https://api.formulasearchengine.com/v1/":): Extraction ratio = \frac{P_a - P_v}{P_a}

, where Pa is the concentration in renal artery, and Pv is the concentration in the renal vein.

For instance, para aminohippuric acid (PAH) is almost completely excreted in the final urine, and thus almost none is found in the venous return (Pv ~0). Therefore, the extraction ration of PAH ~1. This is why PAH is used in PAH clearance to estimate renal plasma flow.

References

  1. Renal Mathematics Texas Tech University Health Sciences Center



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