Estrone sulfotransferase

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In enzymology, an estrone sulfotransferase (EC 2.8.2.4) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + estrone adenosine 3',5'-bisphosphate + estrone 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and estrone, whereas its two products are adenosine 3',5'-bisphosphate and estrone 3-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase. Other names in common use include 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase, estrogen sulfotransferase, estrogen sulphotransferase, oestrogen sulphotransferase, and 3'-phosphoadenylylsulfate:oestrone sulfotransferase. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1AQU, 1AQY, 1BO6, 1G3M, and 1HY3.

References

  • IUBMB entry for 2.8.2.4
  • BRENDA references for 2.8.2.4 (Recommended.)
  • PubMed references for 2.8.2.4
  • PubMed Central references for 2.8.2.4
  • Google Scholar references for 2.8.2.4
  • Adams JB, Poulos A (1967). "Enzymic synthesis of steroid sulphates. 3. Isolation and properties of estrogen sulphotransferase of bovine adrenal glands". Biochim. Biophys. Acta. 146: 493&ndash, 508. PMID 4965224.
  • Rozhin J, Zemlicka J and Brooks SC (1967). "Studies on bovine adrenal estrogen sulfotransferase. Inhibition and possible involvement of adenine-estrogen stacking". J. Biol. Chem. 252: 7214&ndash, 7220.
  • Adams JB, Ellyard RK, Low J (1974). "Enzymic synthesis of steroid sulphates. IX. Physical and chemical properties of purified oestrogen sulphotransferase from bovine adrenal glands, the nature of its isoenzymic forms and a proposed model to explain its wave-like kinetics". Biochim. Biophys. Acta. 370: 160&ndash, 88. PMID 4473218.

External links

The CAS registry number for this enzyme class is 9026-06-6.

Gene Ontology (GO) codes


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