Epilepsy natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

If left untreated, 23% to 71% of patients with a single unprovoked seizure may experience it again within 2 years. After the second unprovoked seizure, the chance of having another seizure increase to 73%. Recurrent seizures with no underlying illness emphasis on epilepsy diagnosis. Common complications of epilepsy include: Status epilepticus, sudden unexpected death, submersion Injury, dental injury, burns, fractures, head injury, soft tissue injury and motor vehicle accidents.

Natural History, Complications, and Prognosis

Natural History

  • If left untreated, 23% to 71% of patients with a single unprovoked seizure may experience it again within 2 years.
  • After the second unprovoked seizure, the chance of having another seizure increase to 73%.
  • Recurrent seizures with no underlying illness emphasis on epilepsy diagnosis.
  • In contrast to adolescent onset epilepsy syndromes most of the childhood onset epilepsy such as benign childhood epilepsy with centrotemporal spikes will go to remission.
  • There is no evidence demonstrating the effect of medical therapy on natural history of epilepsy.[1]

Complications

Prognosis

  • Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
  • Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
  • The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
  • [Subtype of disease/malignancy] is associated with the most favorable prognosis.
  • The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.

References

  1. Samuels, Martin (2017). Samuels's Manual of neurologic therapeutics. Philadelphia: Wolters Kluwer Health. ISBN 9781496360311.
  2. Mattle, Heinrich (2017). Fundamentals of neurology : an illustrated guide. Stuttgart New York: Thieme. ISBN 9783131364524.
  3. Samuels, Martin (2017). Samuels's Manual of neurologic therapeutics. Philadelphia: Wolters Kluwer Health. ISBN 9781496360311.
  4. Buck D, Baker GA, Jacoby A, Smith DF, Chadwick DW (April 1997). "Patients' experiences of injury as a result of epilepsy". Epilepsia. 38 (4): 439–44. PMID 9118849.
  5. van den Broek M, Beghi E (January 2004). "Morbidity in patients with epilepsy: type and complications: a European cohort study". Epilepsia. 45 (1): 71–6. PMID 14692910.
  6. Pack AM, Olarte LS, Morrell MJ, Flaster E, Resor SR, Shane E (April 2003). "Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs". Epilepsy Behav. 4 (2): 169–74. PMID 12697142.
  7. Beghi E, Cornaggia C (September 2002). "Morbidity and accidents in patients with epilepsy: results of a European cohort study". Epilepsia. 43 (9): 1076–83. PMID 12199734.
  8. Hansotia P, Broste SK (1993). "Epilepsy and traffic safety". Epilepsia. 34 (5): 852–8. PMID 8404737.

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