Endothelial lipase

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lipase, endothelial
Identifiers
SymbolLIPG
Entrez9388
HUGO6623
OMIM603684
RefSeqNM_006033
UniProtQ9Y5X9
Other data
LocusChr. 18 q21.1

Endothelial lipase is a form of lipase secreted by vascular endothelial cells in tissues with high metabolic rates and vascularization, such as the liver, lung, kidney, and thyroid gland.[1] Unlike the lipases that hydrolyze triglycerides, endothelial lipase primarily hydrolyzes phospholipids.[1]

It was first characterized in 1999.[2]

References

  1. 1.0 1.1 Yu JE, Han SY, Wolfson B, Zhou Q (2018). "The role of endothelial lipase in lipid metabolism, inflammation, and cancer". Histology and Histopathology. 33 (1): 1–10. doi:10.14670/HH-11-905. PMC 5858721. PMID 28540715.
  2. Jaye M, Lynch KJ, Krawiec J, et al. (1999). "A novel endothelial-derived lipase that modulates HDL metabolism". Nat. Genet. 21 (4): 424–8. doi:10.1038/7766. PMID 10192396.

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