Edward Lawrie Tatum

Jump to: navigation, search

WikiDoc Resources for Edward Lawrie Tatum

Articles

Most recent articles on Edward Lawrie Tatum

Most cited articles on Edward Lawrie Tatum

Review articles on Edward Lawrie Tatum

Articles on Edward Lawrie Tatum in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Edward Lawrie Tatum

Images of Edward Lawrie Tatum

Photos of Edward Lawrie Tatum

Podcasts & MP3s on Edward Lawrie Tatum

Videos on Edward Lawrie Tatum

Evidence Based Medicine

Cochrane Collaboration on Edward Lawrie Tatum

Bandolier on Edward Lawrie Tatum

TRIP on Edward Lawrie Tatum

Clinical Trials

Ongoing Trials on Edward Lawrie Tatum at Clinical Trials.gov

Trial results on Edward Lawrie Tatum

Clinical Trials on Edward Lawrie Tatum at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Edward Lawrie Tatum

NICE Guidance on Edward Lawrie Tatum

NHS PRODIGY Guidance

FDA on Edward Lawrie Tatum

CDC on Edward Lawrie Tatum

Books

Books on Edward Lawrie Tatum

News

Edward Lawrie Tatum in the news

Be alerted to news on Edward Lawrie Tatum

News trends on Edward Lawrie Tatum

Commentary

Blogs on Edward Lawrie Tatum

Definitions

Definitions of Edward Lawrie Tatum

Patient Resources / Community

Patient resources on Edward Lawrie Tatum

Discussion groups on Edward Lawrie Tatum

Patient Handouts on Edward Lawrie Tatum

Directions to Hospitals Treating Edward Lawrie Tatum

Risk calculators and risk factors for Edward Lawrie Tatum

Healthcare Provider Resources

Symptoms of Edward Lawrie Tatum

Causes & Risk Factors for Edward Lawrie Tatum

Diagnostic studies for Edward Lawrie Tatum

Treatment of Edward Lawrie Tatum

Continuing Medical Education (CME)

CME Programs on Edward Lawrie Tatum

International

Edward Lawrie Tatum en Espanol

Edward Lawrie Tatum en Francais

Business

Edward Lawrie Tatum in the Marketplace

Patents on Edward Lawrie Tatum

Experimental / Informatics

List of terms related to Edward Lawrie Tatum


Overview

Edward Lawrie Tatum (December 14, 1909 – November 5, 1975) was an American geneticist. He shared half of the Nobel Prize in Physiology or Medicine in 1958 with George Wells Beadle for showing that genes control individual steps in metabolism. The other half of that year's award went to Joshua Lederberg.

Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments, published in 1941, led them to propose a direct link between genes and enzymatic reactions, known as the "one gene, one enzyme" hypothesis.

Tatum went on to study genetics in bacteria. An active area of research in his laboratory was to understand the basis of Tryptophan biosynthesis in Escherichia coli. Later, Tatum and his student Lederberg showed that E. coli could share genetic information through recombination.

Tatum was born in Boulder, Colorado. He attended college at the University of Chicago and received his PhD in biochemistry from the University of Wisconsin-Madison in 1934. Starting in 1937, he worked at Stanford University, where he began his collaboration with Beadle. He then moved to Yale University in 1945 where he mentored Lederberg. He returned to Stanford in 1948 and then joined the faculty of Rockefeller Institute in 1957. A heavy cigarette smoker, he died in New York City of heart failure complicated by chronic emphysema.

References

  • Nobel Lectures, Physiology or Medicine 1942-1962, Elsevier Publishing Company, Amsterdam, 1964
  • Biographical Memoirs: National Academy of Sciences, Volume 59, National Academy Press, 1990

External links





Linked-in.jpg