EIF2A

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.[1][2][3] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM][3] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.[4][5]

See also

References

  1. Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
  2. Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. PMC 372869. PMID 1620067.
  3. 3.0 3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
  4. Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.
  5. Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMID 28009256.

Further reading



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