EEF2

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.[1][2][3]

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.[3]

EEF2 contains a post transcriptionally modified histadine diphthamide. It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa).[4] The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.

References

  1. Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH (Mar 1990). "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells". Biol Chem Hoppe-Seyler. 370 (10): 1071–5. doi:10.1515/bchm3.1989.370.2.1071. PMID 2610926.
  2. Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2". Proc Natl Acad Sci U S A. 81 (10): 3158–62. doi:10.1073/pnas.81.10.3158. PMC 345240. PMID 6427766.
  3. 3.0 3.1 "Entrez Gene: EEF2 eukaryotic translation elongation factor 2".
  4. Jørgensen R, Merrill AR, Andersen GR (February 2006). "The life and death of translation elongation factor 2". Biochem. Soc. Trans. 34 (Pt 1): 1–6. doi:10.1042/BST20060001. PMID 16246167.

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