Dysplastic nevus medical therapy

Jump to: navigation, search

Dysplastic nevus Microchapters


Patient Information


Historical Perspective




Differentiating Dysplastic nevus from other Diseases

Epidemiology and Demographics

Risk Factors


Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Dysplastic nevus medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Dysplastic nevus medical therapy

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Dysplastic nevus medical therapy

CDC on Dysplastic nevus medical therapy

Dysplastic nevus medical therapy in the news

Blogs on Dysplastic nevus medical therapy

Directions to Hospitals Treating Dysplastic nevus

Risk calculators and risk factors for Dysplastic nevus medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]


The mainstay of therapy for dysplastic nevus is surgery, however radiation therapy or chemotherapy may be administered in metastatic disease.

Medical treatment

Dysplastic nevi are associated with increased risk of melanoma, management includes risk evaluation along with other procedures. The mainstay of therapy for dysplastic nevus is surgery, however radiation therapy or chemotherapy may be incorporated in metastatic disease. Surgical excision of dysplastic nevi is generally recommended with a positive histologic margin.

Dysplastic nevi can be categorized into risk categories:

  • Mildly, mildly-to-moderately, and moderately dysplastic nevi generally appearing as low-risk lesions,
  • Moderately-to-severely and severely dysplastic nevi appearing to carry a higher risk for coexistent or future melanoma.

Chemotherapy regimens

Chemotherapy, however, is indicated for the following patient subgroups:

  • Patients with high risk melanomas (Stage IIB-IV) - Adjuvant therapy using interferon therapy
  • Patients with metastatic disease - First-line therapy using either a single agent or combination regimen.
  • Several single agent and combination regimens have been studied, all with modest impact on survival.

*All current guidelines still recommend enrollment in clinical trials over current available regimens for patients with metastatic disease. Below is a summary of available adjuvant and treatment regimens.

Adjuvant therapy[1]

  1. Interferon alfa-2a (Roferon-A)
  2. Interferon alfa-2b (Intron-A)
  3. Peginterferon alfa-2b (Sylatron)

Metastatic or unresectable melanoma[1]

Either a single agent chemotherapy OR a combination chemotherapy is recommended for metastatic or unresectable melanoma.

  • Single Agent Chemotherapy
  1. Dabrafenib (Tafinlar)
  2. Dacarbazine (DTIC)
  3. Docetaxel (Taxotere)
  4. Interleukin-2 (high dose or maintenance biotherapy)
  5. Imatinib (Gleevec)
  6. Ipilimumab (Yervoy)
  7. Nivolumab (Opdivo)
  8. Paclitaxel (Taxol)
  9. Pembrolizumab (Keytruda)
  10. Temozolomide (Temodar)
  11. Trametinib (Mekinist)
  12. Vemurafenib (Zelboraf)
  • Combination Chemotherapy
  1. Paclitaxel nanoparticle albumin-bound + Bevacizumab + Carboplatin (ABC)
  2. Carboplatin + Paclitaxel
  3. Carboplatin + Paclitaxel + nanoparticle albumin-bound
  4. Carboplatin + Paclitaxel +, Sorafenib
  5. Cisplatin + Dacarbazine ± Carmustine
  6. Cisplatin + Dacarbazine + IL-2 + IFN alfa-2b ± Carmustine
  7. Cisplatin + Paclitaxel + Dacarbazine
  8. Cisplatin + Vinblastine + Dacarbazine
  9. Cisplatin + Vinblastine + Dacarbazine + IL-2 + IFN alfa-2b (sequential biochemotherapy)
  10. Temozolomide + Bevacizumab
  11. Dabrafenib + Trametinib
  12. Ipilimumab + Dacarbazine
  13. Ipilimumab + Nivolumab


  1. 1.0 1.1 Peter Yang and Jeremy Warner. Melanoma. Hemonc.org. Accessed on August 21, 2015. http://hemonc.org/wiki/Melanoma