Dual-specificity kinase

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In enzymology, a dual-specificity kinase (EC 2.7.12.1) is an enzyme that catalyzes the chemical reaction

ATP + a protein ADP + a phosphoprotein

Thus, the two substrates of this enzyme are ATP and protein, whereas its two products are ADP and phosphoprotein.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups dual-specificity kinases (those acting on Ser/Thr and Tyr residues). The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating). Other names in common use include ADK1, Arabidopsis dual specificity kinase 1, CLK1, dDYRK2, and Mps1p. This enzyme participates in cell cycle - yeast.

References

  • IUBMB entry for 2.7.12.1
  • BRENDA references for 2.7.12.1 (Recommended.)
  • PubMed references for 2.7.12.1
  • PubMed Central references for 2.7.12.1
  • Google Scholar references for 2.7.12.1
  • Ali N, Halfter U, Chua NH (1994). "Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine". J. Biol. Chem. 269: 31626&ndash, 9. PMID 7527390.
  • Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO. J. 14: 1655&ndash, 63. PMID 7737118.
  • Menegay HJ, Myers MP, Moeslein FM, Landreth GE (Pt 18). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell. Sci. 113: 3241&ndash, 53. PMID 10954422. Check date values in: |date= (help)
  • Cleghon V (2003). "dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila". Biochem. J. 374: 381&ndash, 91. PMID 12786602.

External links


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