Drotaverine

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Drotaverine
Systematic (IUPAC) name
(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-
diethoxy-3,4-dihydro-2H-isoquinoline
Identifiers
CAS number 985-12-6
ATC code A03AD02
PubChem 1712095
Chemical data
Formula C24H31NO4 
Mol. mass 397.507 g/mol
Pharmacokinetic data
Bioavailability Highly variable
Protein binding 80 to 95%
Metabolism Hepatic
Half life 7 to 12 hours
Excretion Fecal and renal
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Oral, intravenous

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.

A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.[1] It has also been used to accelerate labor.[2]

References

  1. Romics I, Molnár DL, Timberg G; et al. (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int. 92 (1): 92–6. PMID 12823389. doi:10.1046/j.1464-410X.2003.04262.x. 
  2. Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet. 84 (1): 17–22. PMID 14698825. 


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