Drotaverine

Drotaverine
	File:Drotaverine.svg
Clinical data
Routes of; administration	Oral, intravenous
ATC code	A03AD02 (WHO) ;
Pharmacokinetic data
Bioavailability	Highly variable
Protein binding	80 to 95%
Metabolism	Hepatic
Elimination half-life	7 to 12 hours
Excretion	Fecal and renal
Identifiers
	IUPAC name (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-; diethoxy-3,4-dihydro-2H-isoquinoline;
CAS Number	985-12-6;
PubChem CID	1712095;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H31NO4
Molar mass	397.507 g/mol

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.

A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.^[1] It has also been used to accelerate labor.^[2]

References

↑ Romics I, Molnár DL, Timberg G; et al. (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int. 92 (1): 92–6. doi:10.1046/j.1464-410X.2003.04262.x. PMID 12823389.
↑ Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet. 84 (1): 17–22. PMID 14698825.

v t e Drugs for functional gastrointestinal disorders (A03)
Drugs for functional bowel disorders	antimuscarinics: Mebeverine - Dicycloverine - Propantheline papaverine and derivatives: Papaverine - Drotaverine - Moxaverine acting on serotonin receptors: 5-HT₃ antagonists (Alosetron, Cilansetron) - 5HT₄ agonists (Mosapride, Tegaserod) other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl
Belladonna and derivatives (antimuscarinics)	Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine
Propulsives	primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride

Clinical data
File:Drotaverine.svg
Routes of administration	Oral, intravenous
ATC code	A03AD02 (WHO)
Pharmacokinetic data
Bioavailability	Highly variable
Protein binding	80 to 95%
Metabolism	Hepatic
Elimination half-life	7 to 12 hours
Excretion	Fecal and renal
Identifiers
IUPAC name (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7- diethoxy-3,4-dihydro-2H-isoquinoline
CAS Number	985-12-6
PubChem CID	1712095
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₃₁NO₄
Molar mass	397.507 g/mol