Drotaverine
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Drotaverine
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Systematic (IUPAC) name | |
(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7- diethoxy-3,4-dihydro-2H-isoquinoline | |
Identifiers | |
CAS number | |
ATC code | A03 |
PubChem | |
Chemical data | |
Formula | C24H31NO4 |
Mol. mass | 397.507 g/mol |
Pharmacokinetic data | |
Bioavailability | Highly variable |
Protein binding | 80 to 95% |
Metabolism | Hepatic |
Half life | 7 to 12 hours |
Excretion | Fecal and renal |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status | |
Routes | Oral, intravenous |
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.
A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.[1] It has also been used to accelerate labor.[2]
References
- ↑ Romics I, Molnár DL, Timberg G; et al. (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int. 92 (1): 92–6. PMID 12823389. doi:10.1046/j.1464-410X.2003.04262.x.
- ↑ Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet. 84 (1): 17–22. PMID 14698825.