Double-balloon enteroscopy, also known as push-and-pull enteroscopy is an endoscopic technique for visualization of the small bowel. It was developed by Hironori Yamamoto in 2001. It is novel in the field of diagnostic gastroenterology as it is the first endoscopic technique that allows for the entire gastrointestinal tract to be visualized in real time. 
The technique involves the use of a balloon at the end of a special enteroscope camera and an overtube, which is a tube that fits over the endoscope, and which is also fitted with a balloon. The procedure is usually done under general anesthesia, but may be done with the use of conscious sedation. The enteroscope and overtube are inserted through the mouth and passed in conventional fashion (that is, as with gastroscopy) into the small bowel. Following this, the endoscope is advanced a small distance in front of the overtube and the balloon at the end is inflated. Using the assistance of friction at the interface of the enteroscope and intestinal wall, the small bowel is accordioned back to the overtube. The overtube balloon is then deployed, and the enteroscope balloon is deflated. The process is then continued until the entire small bowel is visualized.
Double-balloon enteroscopy has found a niche application in the following settings:
- bleeding from the gastrointestinal tract of obscure cause
- iron deficiency anemia with normal colonoscopy and gastroscopy
- visualization and therapeutic intervention on abnormalities seen on traditional small bowel imaging
- ERCP in post-surgical patients with long afferent limbs
Advantages and disadvantages
- it allows for visualization of the entire small bowel to the terminal ileum
- it allows for the application of therapeutics
- it allows for the sampling or biopsying of small bowel mucosa, for the resection of polyps of the small bowel, and in the placement of stents or dilatation of strictures of the small bowel.
- it allows for access to the papilla in patients with long afferent limbs after Billroth II antrectomy.
The key disadvantage of double-balloon enteroscopy is the time required to visualize the small bowel; this can exceed three hours, and may require that patients be admitted to hospital for the procedure.  There have also been case reports of acute pancreatitis and intestinal necrosis associated with the technique.
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