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ADP-ribosyltransferase 4 (Dombrock blood group)
Symbol(s) ART4; CD297; DO; DOK1
External IDs OMIM: 110600 MGI1202710 Homologene10883
RNA expression pattern

File:PBB GE ART4 207220 at tn.png

More reference expression data

Human Mouse
Entrez 420 109978
Ensembl ENSG00000111339 ENSMUSG00000030217
Uniprot Q93070 na
Refseq NM_021071 (mRNA)
NP_066549 (protein)
NM_026639 (mRNA)
NP_080915 (protein)
Location Chr 12: 14.87 - 14.89 Mb Chr 6: 136.81 - 136.82 Mb
Pubmed search [1] [2]

WikiDoc Resources for ART4


Most recent articles on ART4

Most cited articles on ART4

Review articles on ART4

Articles on ART4 in N Eng J Med, Lancet, BMJ


Powerpoint slides on ART4

Images of ART4

Photos of ART4

Podcasts & MP3s on ART4

Videos on ART4

Evidence Based Medicine

Cochrane Collaboration on ART4

Bandolier on ART4


Clinical Trials

Ongoing Trials on ART4 at Clinical

Trial results on ART4

Clinical Trials on ART4 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on ART4

NICE Guidance on ART4





Books on ART4


ART4 in the news

Be alerted to news on ART4

News trends on ART4


Blogs on ART4


Definitions of ART4

Patient Resources / Community

Patient resources on ART4

Discussion groups on ART4

Patient Handouts on ART4

Directions to Hospitals Treating ART4

Risk calculators and risk factors for ART4

Healthcare Provider Resources

Symptoms of ART4

Causes & Risk Factors for ART4

Diagnostic studies for ART4

Treatment of ART4

Continuing Medical Education (CME)

CME Programs on ART4


ART4 en Espanol

ART4 en Francais


ART4 in the Marketplace

Patents on ART4

Experimental / Informatics

List of terms related to ART4

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

ADP-ribosyltransferase 4 (Dombrock blood group), also known as ART4, is a human gene.[1] ART4 has also been designated as CD297 (cluster of differentiation 297).

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[1]


Further reading

  • Reid ME (2003). "The Dombrock blood group system: a review.". Transfusion. 43 (1): 107–14. PMID 12519438. 
  • Tippett P (1967). "Genetics of the Dombrock blood group system.". J. Med. Genet. 4 (1): 7–11. PMID 6034522. 
  • Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p.". Hum. Genet. 98 (5): 518–21. PMID 8882867. 
  • Koch-Nolte F, Haag F, Braren R; et al. (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.". Genomics. 39 (3): 370–6. PMID 9119374. doi:10.1006/geno.1996.4520. 
  • Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2.". Vox Sang. 79 (1): 53–6. PMID 10971215. 
  • Gubin AN, Njoroge JM, Wojda U; et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.". Blood. 96 (7): 2621–7. PMID 11001920. 
  • Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.". Vox Sang. 81 (1): 49–51. PMID 11520417. 
  • Rios M, Hue-Roye K, Øyen R; et al. (2002). "Insights into the Holley- and Joseph- phenotypes.". Transfusion. 42 (1): 52–8. PMID 11896313. 
  • Rios M, Storry JR, Hue-Roye K; et al. (2002). "Two new molecular bases for the Dombrock null phenotype.". Br. J. Haematol. 117 (3): 765–7. PMID 12028057. 
  • Glowacki G, Braren R, Firner K; et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.". Protein Sci. 11 (7): 1657–70. PMID 12070318. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements.". Biochim. Biophys. Acta. 1730 (3): 173–86. PMID 16140404. doi:10.1016/j.bbaexp.2005.08.001. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.