Dent's disease overview

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Dent's disease Microchapters



Historical Perspective


Differentiating Dent's disease from other Diseases

Epidemiology and Demographics

Natural History, Complications and Prognosis


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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, hypercalciuria, calcium nephrolithiasis, nephrocalcinosis and chronic renal failure.

"Dent's disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with renal failure, X-linked recessive hypophosphataemic rickets, and both Japanese and idiopathic low molecular weight proteinuria.[1]


  1. Mayo Clinic, Division of Nephrology and Hypertension, Mineral Metabolism and Stone Disease