Dent's disease medical therapy

Jump to: navigation, search

Dent's disease Microchapters

Home

Overview

Historical Perspective

Pathophysiology

Differentiating Dent's disease from other Diseases

Epidemiology and Demographics

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Future or Investigational Therapies

Case Studies

Case #1

Dent's disease medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Dent's disease medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Dent's disease medical therapy

CDC on Dent's disease medical therapy

Dent's disease medical therapy in the news

Blogs on Dent's disease medical therapy

Directions to Hospitals Treating Dent's disease

Risk calculators and risk factors for Dent's disease medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Medical Therapy

As of today, there is no agreed-upon treatment of Dent's disease and no therapy has been formally accepted. Most treatment measures are mostly supportive in nature and they include:

  • Thiazide diuretics which have been used with success in reducing the calcium output in urine, but they are also known to cause hypokalemia.
    • In rats with diabetes insipidus thiazide diuretics inhibit the NaCl co-transporter in the renal distal convoluted tubule leading indirectly to less water and solutes being delivered to the distal tubule.[1]
  • Amiloride which also increases distal tubular calcium reabsorption and has been used as a therapy for idiopathic hypercalciuria.
    • A combination of 25 mg of chlorthalidone plus 5 mg of amiloride daily led to a substantial reduction in urine calcium in Dent's patients, however urine pH was "significantly higher in patients with Dent’s disease than in those with idiopathic hypercalciuria (P < 0.03), and supersaturation for uric acid was consequently lower (P < 0.03)."[2]
  • For patients with osteomalacia, Vitamin D or derivatives have been employed, apparently with success.
  • Some lab tests on mice with CLC-5 related tubular damage showed that a high citrate diet preserved renal function and delayed progress of renal disease.[3]

References


Linked-in.jpg