Delta catenin

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catenin (cadherin-associated protein), delta 1
Identifiers
SymbolCTNND1
Alt. symbolsCTNND
Entrez1500
HUGO2515
OMIM601045
RefSeqNM_001331
UniProtO60716
Other data
LocusChr. 11 q12.1
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Identifiers
SymbolCTNND2
Entrez1501
HUGO2516
OMIM604275
RefSeqNM_001332
UniProtQ9UQB3
Other data
LocusChr. 5 p15.2

Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is expressed in the brain where it is important for normal cognitive development.[1] Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins.[2] These catenin-presenilin interaction have implications for cadherin function and regulation of cell-to-cell adhesion.[3]

While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a regulator of the NF-κB transcription factor.[4]

Palmitoylation of delta-catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse structure, and receptor localizations that are involved in memory formation.[5]

References

  1. Israely I, Costa RM, Xie CW, Silva AJ, Kosik KS, Liu X (September 2004). "Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction". Curr. Biol. 14 (18): 1657–63. doi:10.1016/j.cub.2004.08.065. PMID 15380068.
  2. Rubio ME, Curcio C, Chauvet N, Brusés JL (December 2005). "Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1". Mol. Cell. Neurosci. 30 (4): 611–23. doi:10.1016/j.mcn.2005.06.005. PMID 16456928.
  3. Teo JL, Ma H, Nguyen C, Lam C, Kahn M (August 2005). "Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation". Proc. Natl. Acad. Sci. U.S.A. 102 (34): 12171–6. doi:10.1073/pnas.0504600102. PMC 1189325. PMID 16093313.
  4. Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E (February 2006). "p120-catenin mediates inflammatory responses in the skin". Cell. 124 (3): 631–44. doi:10.1016/j.cell.2005.11.043. PMC 2443688. PMID 16469707.
  5. Brigidi GS, Sun Y, Beccano-Kelly D, Pitman K, Jobasser M, Borgland SL, Milnerwood AJ, Bamji SX (January 23, 2014). "Palmitoylation of [delta]-catenin by DHHC5 mediates activity-induced synapse plasticity". Nature Neuroscience. doi:10.1038/nn.3657. PMC 5025286.

See also



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