Dehydro-L-gulonate decarboxylase

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In enzymology, a dehydro-L-gulonate decarboxylase (EC is an enzyme that catalyzes the chemical reaction

3-dehydro-L-gulonate L-xylulose + CO2

Hence, this enzyme has one substrate, 3-dehydro-L-gulonate, and two products, L-xylulose and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming). Other names in common use include keto-L-gulonate decarboxylase, 3-keto-L-gulonate decarboxylase, and 3-dehydro-L-gulonate carboxy-lyase. This enzyme participates in pentose and glucuronate interconversions.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Smiley JD and Ashwell G (1961). "Purification and properties of beta-L-hydroxy acid dehydrogenase II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis". J. Biol. Chem. 236: 357&ndash, 364.

External links

The CAS registry number for this enzyme class is 9024-67-3.

Gene Ontology (GO) codes